Sleepfare

Residence Inn by Marriott Durham Duke University Medical Center Area

★★★ 1108 West Main Street, Durham, US

9 guest rating· 225 reviews

About this hotel

Modern Amenities

Residence Inn by Marriott Durham Duke University Medical Center Area offers free WiFi, complimentary breakfast, and fully equipped kitchens in every room.

Convenient Facilities

Guests can enjoy a fitness centre, 24-hour reception, and on-site mini-market. Additional perks include grocery deliveries, meeting rooms, and free parking.

Prime Location

Located near popular attractions like Brightleaf District and Durham Performing Arts Center, with Duke University Hospital just a short drive away. Raleigh-Durham International Airport is conveniently close for travelers.

Ready to experience comfort and convenience at Residence Inn by Marriott Durham Duke University Medical Center Area? Book your stay now!

Rooms & rates

Pick your dates. Prices are live, not cached.

King Studio with Sofa Bed and Adapted Tub - Mobility Accessible

Sleeps 3 · 45 m² · Extra-large double bed (Super-king size), Sofa bed

  • Desk
  • Air conditioning
  • Single-room air conditioning for guest accommodation
  • Private bathroom
  • Adapted bath

The studio offers a coffee machine, heating, as well as a private bathroom featuring a bath or a shower and a hairdryer. In the well-equipped kitchen, guests will find a stovetop, a dishwasher, kitchenware and a microwave. This wheelchair accessible studio features air conditioning, a seating area with a TV and an adapted bath. The unit offers 2 beds.

King Studio with Sofa Bed and Adapted Tub - Mobility and Hearing Accessible

Sleeps 3 · 45 m² · Extra-large double bed (Super-king size), Sofa bed

  • Desk
  • Air conditioning
  • Single-room air conditioning for guest accommodation
  • Private bathroom
  • Adapted bath

The studio offers a coffee machine, heating, as well as a private bathroom featuring a bath or a shower and a hairdryer. The well-equipped kitchen has a stovetop, a dishwasher, kitchenware and a microwave. This wheelchair accessible studio features air conditioning, a seating area with a TV and an adapted bath. The unit offers 2 beds.

Studio, 1 Queen Bed with Sofa bed (Hearing Accessible)

Sleeps 3 · 40 m² · Queen Bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 Queen Bed and 1 Double Sofa Bed</strong></p><p>426 sq feet </p><br/><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Free local calls, double sofa bed, and safe</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Studio, 1 King Bed with Sofa bed (Hearing Accessible)

Sleeps 3 · 45 m² · King bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 King Bed and 1 Double Sofa Bed</strong></p><p>479 sq feet </p><br/><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Sofa bed, free local calls, and safe</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Suite, 1 Bedroom (Hearing Accessible)

Sleeps 3 · King bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed</strong></p><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Safe, iron/ironing board, and laptop workspace</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Suite, 1 Bedroom (Mobility Accessible, Roll-in Shower)

Sleeps 3 · King bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed</strong></p><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Safe, iron/ironing board, and laptop workspace</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Suite, Multiple Beds (Mobility Accessible, Tub)

Sleeps 5 · 2× Queen Bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>2 Queen Beds and 1 Double Sofa Bed</strong></p><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Safe, iron/ironing board, and laptop workspace</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Suite, 1 Bedroom

Sleeps 3 · 44 m² · King bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 King Bed and 1 Double Sofa Bed OR 1 Queen Bed</strong></p><p>469 sq feet </p><br/><p><b>Layout</b> - Bedroom, living room, and sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Free local calls, double sofa bed, and safe</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Studio, 1 King Bed with Sofa bed

Sleeps 3 · 45 m² · King bed, Sofa bed

  • Desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom
  • Kitchen

<p><strong>1 King Bed and 1 Double Sofa Bed</strong></p><p>480 sq feet </p><br/><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Sofa bed, free local calls, and safe</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Hardwood flooring in room</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Studio, 1 King Bed with Sofa bed (Mobility Accessible, Tub)

Sleeps 3 · 45 m² · King bed, Sofa bed

  • Desk
  • Low-height desk
  • Desk chair
  • Laptop-friendly workspace
  • Private bathroom

<p><strong>1 King Bed and 1 Double Sofa Bed</strong></p><p>479 sq feet </p><br/><p><b>Layout</b> - Separate sitting area</p><p><b>Internet</b> - Free WiFi </p><p><b>Entertainment</b> - 32-inch Smart TV with premium channels and Netflix</p><p><b>Food & Drink</b> - Kitchen with refrigerator, stovetop, microwave, and dishwasher</p><p><b>Sleep</b> - Blackout drapes/curtains and bed sheets </p><p><b>Bathroom</b> - Private bathroom, shower/tub combination, free toiletries, and a hair dryer</p><p><b>Practical</b> - Sofa bed, free local calls, and safe</p><p><b>Comfort</b> - Fresh bed sheets (on request), fresh towels (on request), and climate-controlled air conditioning</p><p><b>Accessibility</b> - Low-height counters and sink, low-height bed, grab bar in bathtub, bathtub grab bar height (inches): 24, low bed height (inches): 24, hardwood flooring in room, wheelchair-accessible vanity height (inches): 33, low-height desk, wheelchair-accessible bathroom vanity, wheelchair-width doorways, wheelchair accessible, lever door handles, low-height electrical outlets in bathroom, low desk height (inches): 29, toilet grab bar height (inches): 34, braille signage, wheelchair-accessible doorway width (inches): 34, thin carpet in room, low-height view port in door, accessible bathtub, closed-captioned TV, lowered counter and sink height (inches): 33, low-height door lock, and portable bathtub seat</p><p><b>Eco-friendly</b> - Energy-saving switches, recycling bin, and LED light bulbs</p><p><b>Need to Know</b> - Housekeeping on request</p><p>Non-Smoking</p>

Amenities

  • Free WiFi
  • Fitness facilities
  • Accessible parking
  • Parking
  • Bar
  • Screens / Barriers between staff and guests for safety
  • Air conditioning
  • Pets allowed
  • 24-hour front desk
  • Business center
  • Non-smoking rooms
  • Non-smoking throughout
  • Family rooms
  • BBQ facilities
Show all 57 amenities
  • Car hire
  • Cashless payment available
  • CCTV in common areas
  • CCTV outside property
  • Cleaning standards that are effective against Coronavirus
  • Concierge service
  • Contactless check-in/check-out
  • Dry cleaning
  • Express check-in/check-out
  • Facilities for disabled guests
  • Fax/photocopying
  • Fire extinguishers
  • First aid kit available
  • Grocery deliveries
  • Guest rooms disinfected between stays
  • Guests can opt-out any cleaning services during stay
  • Hand sanitizer in guest room and key areas
  • Heating
  • Key access
  • Key card access
  • Laundry
  • Laundry washed per local authority guidelines
  • Lift / Elevator
  • Luggage storage
  • Meeting/banquet facilities
  • Minimarket on site
  • Outdoor fireplace
  • Outdoor furniture
  • Physical distancing in dining areas
  • Physical distancing rules followed
  • Picnic area
  • Safety deposit box
  • Sanitized tableware & silverware
  • Security alarm
  • Shared lounge/TV area
  • Shared stationery like menus, pens are removed
  • Shuttle service
  • Shuttle service (free)
  • Smoke alarms
  • Staff adhere to local safety protocols
  • Terrace
  • Visual aids: Braille
  • Wheelchair accessible

Location

© OpenStreetMap contributors

1108 West Main Street, Durham, US

Check-in
from 03:00 PM to 12:00 AM
Check-out
until 12:00 PM

What guests say9225 reviews

+ Friendly and attentive staff+ Great location near the hospital− Breakfast quality needs improvement− Lumpy bed in the room
Cleanliness8.3
Service9.8
Location9.3
Room Quality8.3
Amenities9.3
Value for Money9.3

Guest review

1.0

− There was hardly anyone working and it was difficult to get in touch with the front desk. Gave us a queen when we reserved a king and tried to argue that it was a king. Also gave us a pack and play, not a crib, that was very dirty with just a hotel sheet folded in the bottom.

Jordan · US · 2026-07-19

Good Stay

8.0

We stayed here for a few days last month while my son attended a camp at Duke. Our room was spacious and clean. The parking situation can be difficult depending on what time you arrive. There were no garage spots or lot spots so we just parked across the street, it seems they are doing contruction to make that a larger lot. Breakfast ends at 9am which would be great to extend till 10. All the hotel employees we encountered were extremely friendly. If you are a light sleeper they mention having sound machines due to the train noise. It didn't really bother us. We were able to walk to quite a few restaurants in the area that were great. All in all I would choose this spot again.

I4541GLamym · CHARLOTTE, NORTH CAROLINA · 2026-07-02

A Masterclass in Hostility

2.0

Most hotels train their staff in hospitality. The Residence Inn Durham appears to be the product of an accidental registration for the "open hostility" seminar and a game-time decision to fully commit to the curriculum. The staff here have a shocking commitment to discourtesy and everyone we encountered seemed genuinely offended by the presence of guests. The room itself had the exhausted ambiance of a regional airport lounge. Every surface suggested a long-standing disagreement with disinfectant and carpets appeared to have absorbed several economic downturns. The “kitchen” featured the fun and exciting challenge of discovering which appliances/utensils still qualified as functional. Most did not. If you’ve ever wondered what the complete philosophical rejection of housekeeping looks like, look no further than this hotel. Management cites “COVID-19” as their justification for not cleaning rooms. While I understand that some hotels offer the option (keyword OPTION!) to forgo daily cleaning services during longer stays, invoking pandemic protocol to avoid replacing towels for 4+ days in 2026 is quite bold. The parking situation deserves academic study. You pay for parking, but not in the charmingly old-fashioned sense where your car remains near the hotel. Instead, the hotel invites you to on an odyssey to their auxiliary lot. Despite what they may tell you it is not close or convenient, particularly in the rain. In fairness, the hotel did succeed in one respect: it inspired immediate brand loyalty to every competing property within The Triangle.

hotelcritic00876 · NEW YORK CITY, NEW YORK · 2026-05-26

Wonderful experience!

10.0

I had a wonderful experience here, even though it was only for a day. Tiffani at the front desk made the experience well worth it. She was very informative and offered excellent customer service.

160marcusy · 2026-04-17

Good to know

Guests are required to show a photo ID and credit card upon check-in. Please note that all Special Requests are subject to availability and additional charges may apply.

A deposit may be required at the property.

›Internet

WiFi is available in all areas and is free of charge.

›Children and extra bed policy

Children of any age are allowed.

Children up to and including 11 years old stay for free when using an existing bed.

You haven't added any cots.

You haven't added any extra beds.

›Pets

Pets are allowed. Charges may be applicable.

›Groups

When booking more than 9 rooms, different policies and additional supplements may apply.

›Parking

Public parking is possible on site (reservation is not needed) and costs USD 15 per day.